Although his work is cited in almost all historical reviews of studies into the mechanisms of atherosclerosis, little is known about Ignatowski's life and the conditions under which he worked. Ignatowski's pioneering experiments became classic and were reproduced by many research scientists all over the world, which ultimately led to our current understanding of the atherosclerotic process. 10,11 Since 1912, extensive research has been conducted on the mechanism of atherosclerosis. 9 The same year, Nikolai Anichkov and Semen Chalatov reproduced Ignatowski's experiments and showed that atherosclerosis can be caused by cholesterol. Ignatowski's experimental protocols, Theodor Fahr produced early atherosclerosis in 5 to 8 months and severe atherosclerotic damage to the aorta, with elevated blood pressure, in 9 to 10 months. These pioneering experiments began an era of metabolic studies into the mechanism of atherosclerosis. Rabbits fed with animal proteins soon developed pronounced atherosclerosis of the aorta. 1,2 Research into the causes of atherosclerosis began in 1907, when Alexander Ignatowski began to feed rabbits a diet of full-fat milk, eggs, and meat. The understanding of the pathogenesis of atherosclerosis is often called one of the greatest discoveries of the 20th century.
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